Some statins are more likely to interact with colchicine than others. Statins are a group of medications that treat high cholesterol. Or they may suggest an alternative medication. It’s likely that they’ll decrease your colchicine dose. But if you can’t, talk to your healthcare provider. It’s a good idea to avoid grapefruit juice and grapefruit while taking colchicine. This can increase the risks of side effects like muscle pain or damage. The interaction between colchicine and grapefruit can cause higher levels of colchicine. Grapefruit and grapefruit juice block the enzyme (protein) that metabolizes colchicine. Colchicine is broken down (metabolized) by the liver. Grapefruit and grapefruit juice can interact with many medications, including colchicine. Your healthcare provider and pharmacist can use it to check for colchicine interactions. Before starting colchicine, create an updated list of your medications. But this isn’t a complete list of possible interactions. Most colchicine interactions raise your risk of side effects like muscle pain.īelow, we discuss seven of the most important colchicine interactions to know. Like most medications, colchicine can have drug interactions. It’s also approved to treat an autoimmune condition called familial Mediterranean fever. It works by blocking multiple inflammatory processes that occur during gout attacks. It gets harder to treat the longer you wait.Ĭolchicine (Colcrys, Mitigare) is a medication that’s used to prevent and treat gout attacks. If you experience a gout attack, you’ll want to start medication right away. During a gout attack, you may experience pain and swelling in a specific joint. Gout occurs when a substance called uric acid builds up in the joints. If you have gout, you know how painful a gout attack can be.
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